Flexeril must only be used to 1 to 2 weeks. A longer and regular use of the drug for a month or more can also be a life taking amount. However, all these amounts can vary in different individuals. A combination of age, sex, weight, other medical conditions, and genetic factors play a significant role in the determination of lethal dose. Any initial overdose of Flexeril can be treated with appropriate treatment. The detoxification of the drug, along with the treatment of the symptoms, can completely cure a person.
In cases of emergency, steps to prevent respiratory and cardiac extremes can be the best measures. Gastric lavage can help in preventing more absorption of the drug. Thus appropriate treatment is helpful in cases of overdose of the drug. We strive to be fully transparent in all of our relationships. To that end, we want you to be aware that Addiction Treatment Services is compensated by Phoenix Behavioral Healthcare for the work Addiction Treatment Services does in the development and operation of this site.
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Skip to content. Class Flexeril is a brand name of cyclobenzaprine. Mode of action Cyclobenzaprine, like other muscle relaxants, is only used orally. Half-life and elimination The half-life of Flexeril ranges from 8 to 37 hours. Use and effects Most physicians prescribe Flexeril for muscle spasm due to acute musculoskeletal conditions.
Is Flexeril lethal? These effects can be any one of the following. Lethal dose 3 to 5 times than the prescribed dose of Flexeril is considered to be an overdose. These same symptoms are fairly common after poisoning and overdose[ 5 ]. Gastrointestinal effects range from nausea and vomiting to constipation and loss of appetite. High doses might produce hepatic damage with steatosis.
Acute renal insufficiency has been reported in case reports[ 6 ]. Acid base disturbances manifest as metabolic acidosis. Rhabdomyolysis is an uncommon complication that may develop with prolonged agitation as was most likely in the case presented above. We found only one case description where cyclobenzaprine's range of toxicity was associated with significant Rhabdomyolysis[ 7 ]. Psychiatric effects may occur with therapeutic or overdose levels manifesting as agitation, hallucinations, and even precipitation of acute manic psychosis[ 8 ].
The management of cyclobenzaprine overdose should follow the same pathway as any tricyclic drug. Gastric decontamination is fairly effective because the Anticholinergic effects of cyclobenzaprine delay gastric emptying and therefore it becomes possible to obtain tablet residues even after significant time elapse.
The mechanism of action of sodium bicarbonate is unknown. Severe Anticholinergic effects can be reversed with the use of physostigmine salicylate 1 to 3 mg IV. Careful cardiac and hemodynamic monitoring is recommended in the first 48 hours to manage signs of cardiac toxicity and hypotension.
Neuropharmacology , — Article Google Scholar. Spine 29 23 :E—7. American journal of forensic Med Pathology , — Douglass MA, Levine DP: hallucinations in an elderly patient taking recommended dose of cyclobenzaprine. Archives of internal Medicine , J Toxicology clinical toxicology , — Clinical psychiatry , CAS Google Scholar.
Annals of Emergency Medicine , — PubMed Article Google Scholar. Ambre JJ: Cyclobenzaprine overdosage letter. Annals of internal Medicine. Newton RW: physostigmine salicylate in the treatment of tricyclic antidepressant overdose.
JAMA , — Download references. Division of Hospital Medicine, Dept. You can also search for this author in PubMed Google Scholar. Correspondence to Shiven B Chabria. Large doses can also lead to an overdose. Seizures, confusion, dizziness, and loss of consciousness are a few symptoms associated with a dose that overwhelms the body.
Rapid medical attention is required, as this is a life-threatening emergency. Researchers look at emergency room visits and calls to poison control centers when attempting to determine how often people abuse a drug. After all, people with an addiction issue tend to take a lot of the target drug, and they often take doses too close together. Many people like this need medical help. That data suggests that Flexeril abuse is relatively common. The U. Drug Enforcement Administration says that emergency room visits due to Flexeril rose percent between and And in , close to 11, phone calls to poison control centers were due to this drug.
What happens now? Treatment can help. Since , it has extended resources, advocacy and thought leadership to its members. Footprints has the Gold Seal of Approval, which means we possess the highest standard of safety and quality of care. LegitScript is a third-party certification that demonstrates Footprints complies with all applicable laws and regulations, including our ongoing commitment to transparency.
NALGAP is The Association of Lesbian, Gay, Bisexual, Transgender Addiction Professionals and Their Allies is a membership organization founded in and dedicated to the prevention and treatment of alcoholism, substance abuse, and other addictions in lesbian, gay, bisexual, transgender, queer communities.
NAADAC , the Association for Addiction Professionals, represents the professional interests of more than , addiction counselors, educators and other addiction-focused health care professionals in the United States, Canada and abroad. What Does Flexeril Do? What Does Abuse Look Like?
An addiction is characterized by: Big doses. Your doctor tells you to take one pill at a time. You take three.
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